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750332C

Avanti

14:0 Cardiolipin (sodium salt)

1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (sodium salt), chloroform

Synonym(s):

1,1′,2,2′-tetratetradecanoyl cardiolipin (sodium salt); CL(1′-[14:0/14:0],3′-[14:0/14:0])

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About This Item

Empirical Formula (Hill Notation):
C65H124Na2O17P2
CAS Number:
63988-21-6
Molecular Weight:
1285.60
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

solution

packaging

pkg of 1 × 2.5 mL (750332C-25mg)
pkg of 2 × 4 mL (750332C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 750332C

concentration

10 mg/mL (750332C-25mg)
25 mg/mL (750332C-200mg)

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

General description

Cardiolipin, the mitochondrial-specific phospholipid, helps maintain mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and the proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy (Barth syndrome). Cardiolipin has also been shown as a signaling molecule in apoptosis.

Application

14:0 Cardiolipin (sodium salt) has been used for the mass spectrometry (MS) analysis to determine the structure of lipid A.

Packaging

5 mL Clear Glass Sealed Ampule (750332C-200mg)
5 mL Clear Glass Sealed Ampule (750332C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm
Yoon SH, et al.
Rapid Communications in Mass Spectrometry, 30(23), 2555-2560 (2016)
Vladimir B Ritov et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 831(1-2), 63-71 (2005-12-13)
Cardiolipin is a phospholipid that is specific to the inner mitochondrial membrane and essential for numerous mitochondrial functions. Accordingly, a quantitative assay for cardiolipin can be a valuable aspect of assessing mitochondrial content and functional capacity. The current study was
Role of cardiolipin alterations in mitochondrial dysfunction and disease
Chicco AJ and Sparagna GC
American Journal of Physiology. Cell Physiology, 292(1), C33-C44 (2007)
Paulina Perczyk et al.
Biochimica et biophysica acta. Biomembranes, 1862(6), 183239-183239 (2020-03-03)
Soil bacteria are decomposer organisms crucial for the biodegradation of organic pollutants, mineralization of dead organic matter and the turnover of biogenic elements. In their environment they are constantly exposed to membrane-lytic enzymes emitted to the soil by other microorganisms
Erum Malik et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183141-183141 (2019-12-04)
Linearized esculentin 2 EM (E2EM-lin) from the frog, Glandirana emeljanovi was highly active against Gram-positive bacteria (minimum lethal concentration ≤ 5.0 μM) and strongly α-helical in the presence of lipid mimics of their membranes (>55.0%). The N-terminal α-helical structure adopted by E2EM-lin showed
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