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QBD10201

Sigma-Aldrich

Biotin-dPEG®3-MAL

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C27H43N5O8S
Molecular Weight:
597.72
UNSPSC Code:
51171641
PubChem Substance ID:
329823891
NACRES:
NA.22
Pricing and availability is not currently available.

Assay

>90%

form

solid or viscous liquid

reaction suitability

reagent type: cross-linking reagent
reaction type: Biotinylations
reactivity: thiol reactive
reagent type: linker

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(NCCCOCCOCCOCCCNC(CCCCC1C2NC(NC2CS1)=O)=O)CCN3C(C=CC3=O)=O

InChI

1S/C27H43N5O8S/c33-22(6-2-1-5-21-26-20(19-41-21)30-27(37)31-26)28-10-3-13-38-15-17-40-18-16-39-14-4-11-29-23(34)9-12-32-24(35)7-8-25(32)36/h7-8,20-21,26H,1-6,9-19H2,(H,28,33)(H,29,34)(H2,30,31,37)

InChI key

QCEXTKIIGXBNCN-UHFFFAOYSA-N

Application

Biotin-dPEG®3-MAL can be used as a cross-linking reagent in biotinylation reaction.[1]

Features and Benefits

Biotin-dPEG®3-MAL takes advantage of the well-known, specific Michael reaction between a maleimide group and a free sulfhydryl to allow site-specific biotin labeling of molecules in aqueous media within the pH range of 6.5 – 7.5. The single molecular weight dPEG® spacer (24.9 Å) provide precise spacing between the biotin moiety and the labeled molecule. The dPEG® spacer imparts water solubility to the labeled molecule while reducing immunogenicity, aggregation, and precipitation of labeled biomolecules or other labeled compounds.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Amanda R Smith et al.
Retrovirology, 16(1), 28-28 (2019-10-24)
PIE12-trimer is a highly potent D-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved hydrophobic pockets at the base of the gp41 N-trimer with sub-femtomolar affinity. This extremely high affinity for the transiently

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