The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in
European journal of pharmacology, 204(3), 227-233 (1991-11-12)
When rats received a single i.p. injection of clomipramine (20 mg/kg), clomipramine and desmethylclomipramine were rapidly distributed into the brain and their concentrations were markedly higher in the brain than in the serum, while the concentration of the metabolite in
American journal of veterinary research, 61(1), 80-85 (2000-01-12)
To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages. 9 male and 9 female Beagles. Clomipramine was administered orally at a dose of 1, 2
Veterinary and human toxicology, 36(4), 309-310 (1994-08-01)
A 27-y-old male was admitted deeply comatosed 5-6 h after taking approximately 15 g clomipramine. The prominent feature of the case was a biphasic course of clomipramine and desmethylclomipramine serum concentrations, possibly caused by delayed drug absorption. Clinically, 2 serious
Plasma concentrations after a clomipramine intoxication.
L M Stolk et al.
Journal of analytical toxicology, 22(7), 612-613 (1998-12-10)
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