666548
7-Methyladenine
97%
Synonym(s):
6-Amino-7-methylpurine, 7-Methyl-7H-purin-6-amine
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About This Item
Empirical Formula (Hill Notation):
C6H7N5
CAS Number:
Molecular Weight:
149.15
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
97%
form
solid
mp
346-350 °C
SMILES string
Cn1cnc2ncnc(N)c12
InChI
1S/C6H7N5/c1-11-3-10-6-4(11)5(7)8-2-9-6/h2-3H,1H3,(H2,7,8,9)
InChI key
HCGHYQLFMPXSDU-UHFFFAOYSA-N
Application
<ul>
<li><strong>Biomarkers of Cigarette Smoking and DNA Methylating Agents:</strong> Study on 7-Methyladenine highlights its role as a biomarker of DNA damage from exposure to methylating agents (Harroun et al., 2017).</li>
</ul>
<li><strong>Biomarkers of Cigarette Smoking and DNA Methylating Agents:</strong> Study on 7-Methyladenine highlights its role as a biomarker of DNA damage from exposure to methylating agents (Harroun et al., 2017).</li>
</ul>
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Luna Laera et al.
Cancers, 11(7) (2019-07-10)
Background: Mutations in the oncosuppressor gene BReast CAncer susceptibility gene 2 (BRCA2) predispose to aggressive forms of prostate cancer which show poor response to taxane-based therapy, the standard treatment for castration-resistant, aggressive prostate cancer. Herein, we addressed the question whether
H G Mandel et al.
Carcinogenesis, 15(7), 1393-1398 (1994-07-01)
Earlier studies showed that urine of rats which had been injected with the methylating agent N-[3H-methyl]-N-nitrosourea contained a previously undetected metabolic product, 7-[3H-methyl]adenine. This methylpurine, undoubtedly derived from alkylation of nucleic acids followed by depurination, was not labeled when 14C-methyl-labeled
B Tudek et al.
Acta biochimica Polonica, 46(3), 785-799 (2000-03-04)
The most abundant lesion formed in DNA upon modification with methylating agents 7-methylguanine, under alkaline conditions is converted into 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7MeGua). We have previously shown that treatment of dimethylsulfate methylated DNA with NaOH creates mutagenic base derivatives leading to a
H G Mandel et al.
Analytical biochemistry, 217(2), 292-297 (1994-03-01)
We have developed a procedure for isolating and quantifying 7-methyladenine from rat urine following the administration to the rat of methylating agents, such as dimethylnitrosamine. Urinary 7-methyladenine and its trideutero isomer, added as an internal standard, were precipitated with silver
Scott G Harroun et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 176, 1-7 (2017-01-07)
3-Methyladenine and 7-methyladenine are biomarkers of DNA damage from exposure to methylating agents. For example, the concentration of 3-methyladenine increases significantly in the urine of cigarette smokers. Surface-enhanced Raman spectroscopy (SERS) has shown much potential for detection of biomolecules, including
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