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Key Documents

SAB3500023

Sigma-Aldrich

Anti-α-Tubulin from chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-LIS3, Anti-TUBA1A, Anti-TUBA3, Anti-Tubulin alpha-1A

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TUBA1A(7846)

General description

Tubulin α 1A (TUBA1A) is a member of α-tubulin gene family. It is encoded by the gene mapped to human chromosome 12q13.12. Tubulin α 1A is a vital structural subunit of microtubules that are temporarily expressed in almost all post-mitotic neurons during neuronal development. The encoded protein structure contains a core of two β-sheets enclosed by α-helices. TUBA1A is characterized with an amino-terminal domain having guanine nucleotide-binding region, an intermediate domain and a carboxy-terminal domain.

Immunogen

Tubulin antibody was raised against a 16 amino acid peptide near the amino terminus of human Tubulin.

Application

Anti-α-tubulin from chicken has been used for Western blotting and immunohistochemistry.

Biochem/physiol Actions

Gene mutation of tubulin α-1A (TUBA1A) is observed in perisylvian asymmetrical polymicrogyria, polymicrogyria-like cortical dysplasia, and microlissencephaly in fetal cases. Alteration in the expression of the gene impairs neural migration and causes lissencephaly (LIS).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500023.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.
Description
Pricing

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Houju Fu et al.
Evidence-based complementary and alternative medicine : eCAM, 2011, 606514-606514 (2010-10-29)
Although it is well known that acupuncture has beneficial effects on a variety of medical conditions especially in pain relief, nausea, and vomiting, it remains controversial whether it has positive impact on the female reproduction. The present study aimed to
The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9
Ulf Brockmeier
PLoS ONE (2011)
Robert C Twining et al.
Nature neuroscience, 20(3), 459-469 (2017-01-24)
Adaptive social behavior requires transmission and reception of salient social information. Impairment of this reciprocity is a cardinal symptom of autism. The amygdala is a critical mediator of social behavior and is implicated in social symptoms of autism. Here we
Neuromuscular study of early branching Diuronotus aspetos (Paucitubulatina) yields insights into the evolution of organs systems in Gastrotricha
Nicolas Bekkouche and Katrine Worsaae
Zoological letters, 2(21) (2016)
TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins.
Kumar RA, et.al
Human Molecular Genetics, 19(14), 2817-2827 (2010)

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