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S1439

Sigma-Aldrich

Monoclonal Anti-SERCa2 ATPase antibody produced in mouse

clone IID8

Synonym(s):

Monoclonal Anti-Sarcoplasmic or Endoplasmic Reticulum Ca2+ ATPase

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About This Item

MDL number:
MFCD00802884
UNSPSC Code:
12352203
NACRES:
NA.41

antibody form

purified from hybridoma cell culture

Quality Level

200

antibody product type

primary antibodies

clone

IID8, monoclonal

species reactivity

bovine, canine, rat, human, pig, rabbit

technique(s)

immunocytochemistry: suitable
immunohistochemistry (frozen sections): 1:500
indirect immunofluorescence: suitable
western blot: 1:500-1:5,000

UniProt accession no.

P16615

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATP2A2(488)
rat ... Atp2a2(29693)

Immunogen

purified canine cardiac sarcoplasmic reticulum.

Physical form

Supplied as a solution in PBS containing 0.05% sodium azide.

Other Notes

Not suitable for immunoblotting in rat SERCA2.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Luca Hegedüs et al.
Frontiers in oncology, 7, 95-95 (2017-06-10)
Several new therapeutic options emerged recently to treat metastatic melanoma; however, the high frequency of intrinsic and acquired resistance among patients shows a need for new therapeutic options. Previously, we identified the plasma membrane Ca2+ ATPase 4b (PMCA4b) as a
Luca Hegedũs et al.
International journal of cancer, 140(12), 2758-2770 (2016-11-05)
Oncogenic mutations of BRAF lead to constitutive ERK activity that supports melanoma cell growth and survival. While Ca2+ signaling is a well-known regulator of tumor progression, the crosstalk between Ca2+ signaling and the Ras-BRAF-MEK-ERK pathway is much less explored. Here
Haibin Gong et al.
Experimental and therapeutic medicine, 12(3), 1355-1362 (2016-09-08)
The study was conducted to examine the effects of ICI 118,551 on the systolic function of cardiac muscle cells of rats in heart failure and determine the molecular mechanism of selective β2-adrenergic receptor (β2-AR) antagonist on these cells. The chronic
Ning Li et al.
Traffic (Copenhagen, Denmark), 18(4), 232-241 (2017-02-06)
Darier's disease (DD) is an autosomal dominantly inherited skin disorder caused by mutations in sarco/endoplasmic reticulum Ca2+ -ATPase 2 (SERCA2), a Ca2+ pump that transports Ca2+ from the cytosol to the endoplasmic reticulum (ER). Loss of desmosomes and keratinocyte cohesion
Igor Gamayun et al.
Cell chemical biology, 26(4), 571-583 (2019-02-26)
Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport within the endomembrane system. Here, we show that ES1 impairs Ca2+ homeostasis by enhancing the Ca2+ leakage from mammalian ER. A comparison
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