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HPA005785

Sigma-Aldrich

Anti-CD44 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

CD44 Antibody - Anti-CD44 antibody produced in rabbit, Cd44 Antibody, Anti-CD44 antigen precursor antibody produced in rabbit, Anti-CDw44 antibody produced in rabbit, Anti-Epican antibody produced in rabbit, Anti-Extracellular matrix receptor-III antibody produced in rabbit, Anti-GP90 lymphocyte homing/adhesion receptor antibody produced in rabbit, Anti-HUTCH-I antibody produced in rabbit, Anti-Heparan sulfate proteoglycan antibody produced in rabbit, Anti-Hermes antigen antibody produced in rabbit, Anti-Hyaluronate receptor antibody produced in rabbit, Anti-PGP-1 antibody produced in rabbit, Anti-Phagocytic glycoprotein I antibody produced in rabbit

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About This Item

MDL number:
UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:1000-1:2500

immunogen sequence

DDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPR

UniProt accession no.

application(s)

research pathology

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CD44(960)

General description

The CD44 (cell-surface glycoprotein) gene encodes a transmembrane glycoprotein and has 20 exons. It is mapped to human chromosome 11p13.

Immunogen

CD44 antigen precursor recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-CD44 antibody produced in rabbit has been used:
  • in immunohistochemistry
  • in western blotting
  • in immunofluorescence staining to characterize the immunophenotype of the mammospheres

Biochem/physiol Actions

CD44 is a hyaluronic acid receptor that regulates cell repair, adhesion and inflammation. This protein has been implicated in cancer aggressiveness, metastasis and growth. Thus, CD44 is used as a cell-surface marker for several cancers . Anti-CD44 antibody is specific for CD44 in humans.
Overexpression of CD44 (cell-surface glycoprotein) leads to esophageal squamous cell carcinoma (ESCC). It is involved in cell-cell and cell-extracellular matrix interactions. It plays an important role in lymphocyte homing and lymphocyte activation.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST83079

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Michael G Monaghan et al.
Development (Cambridge, England), 143(3), 473-482 (2015-12-18)
The elucidation of mechanisms in semilunar valve development might enable the development of new therapies for congenital heart disorders. Here, we found differences in proliferation-associated genes and genes repressed by VEGF between human semilunar valve leaflets from first and second
BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems
Patnaik SK, et al.
Nucleic Acids Research, D1023-D1029 (2011)
The role of CD44 and ERM proteins in expression and functionality of P-glycoprotein in breast cancer cells
Pokharel D, et al.
Molecules (Basel), 290-290 (2016)
Helen Schneck et al.
PloS one, 10(12), e0144535-e0144535 (2015-12-24)
Circulating tumor cells (CTCs) are the potential precursors of metastatic disease. Most assays established for the enumeration of CTCs so far-including the gold standard CellSearch-rely on the expression of the cell surface marker epithelial cell adhesion molecule (EpCAM). But, these
Toward early detection of Helicobacter pylori-associated gastric cancer
Walker R, et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 21(2), 196-203 (2018)

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