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C4238

Sigma-Aldrich

CNS-1102

>98% (HPLC), solid

Synonym(s):

Aptiganel hydrochloride, Cerestat, N-(3-Ethylphenyl)-N-methyl-N’-1-naphthalenylguanidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H21N3 · HCl
CAS Number:
137160-11-3
Molecular Weight:
339.86
MDL number:
MFCD00867728
UNSPSC Code:
12352200
PubChem Substance ID:
24277735
NACRES:
NA.77

Assay

>98% (HPLC)

form

solid

color

white

solubility

H2O: soluble 17 mg/mL
DMSO: soluble 20 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].CCc1cccc(c1)N(C)C(=N)Nc2cccc3ccccc23

InChI

1S/C20H21N3.ClH/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19;/h4-14H,3H2,1-2H3,(H2,21,22);1H

InChI key

CKAKVKWRMCAYJD-UHFFFAOYSA-N

Biochem/physiol Actions

CNS-1102 acts as a neuroprotective agent and might exhibit therapeutic effects against acute stroke and traumatic brain injury.
Noncompetitive NMDA glutamate receptor antagonist.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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K W Muir et al.
Annals of the New York Academy of Sciences, 765, 279-289 (1995-09-15)
The high affinity noncompetitive N-methyl-D-aspartate receptor antagonist CNS 1102 (aptiganel hydrochloride, Cambridge NeuroScience, Cambridge, MA.) is neuroprotective in preclinical models of stroke when administered as pretreatment or up to 60 minutes postischemia, and has potential for treatment of acute stroke

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