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Y0000511

Dexamethasone isonicotinate for impurity C identification

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dexamethasone 21-isonicotinate

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About This Item

Empirical Formula (Hill Notation):
C28H32FNO6
CAS Number:
Molecular Weight:
497.56
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

dexamethasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1

InChI key

BQTXJHAJMDGOFI-NJLPOHDGSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone isonicotinate for impurity C identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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A C Moreira et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 24(7), 339-341 (1992-07-01)
A previous study in an untreated girl with 17 alpha-hydroxylase deficiency syndrome (17-OHDS) indicated that in the absence of cortisol production, ACTH and corticosterone (B) may interact to modulate the brain-pituitary-adrenocortical system. The ACTH-B interplay was further examined in this
Effect of dexamethasone isonicotinate on milk yield in ketotic cows.
H Philipp et al.
The Veterinary record, 128(18), 427-427 (1991-05-04)
L Tossin et al.
Annals of allergy, 63(4), 292-296 (1989-10-01)
To determine whether treatment with aerosolized dexamethasone isonicotinate inhibits asthmatic reactions and the associated increase in airway responsiveness induced by toluene diisocyanate (TDI), we studied six sensitized subjects with previously demonstrated dual or late asthmatic reaction after inhalation challenge with
M Kusenda et al.
Journal of veterinary internal medicine, 27(1), 200-206 (2012-12-01)
Dexamethasone frequently is used for treatment of ketosis in dairy cows, but its effects are not fully understood. Dexamethasone treatment affects whole body insulin sensitivity. Twelve German Holstein cows, 2-4 weeks postpartum, 5 days after omentopexy to correct left abomasal
L Andersson et al.
Nordisk veterinaermedicin, 36(1-2), 13-18 (1984-01-01)
In a cross-over study of six clinically healthy cows in early lactation, injection of 10 mg dexamethasone isonicotinate caused significantly increased plasma glucose for six days and significantly decreased milk yield for one day. The corresponding effects of 10 mg

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