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Key Documents

Y0000317

Mesna impurity D

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2,2′-Dithiobisethanesulfonic acid, 2,2′-(Disulphanediyl)bis(ethanesulphonic acid)

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About This Item

Empirical Formula (Hill Notation):
C4H10O6S4
CAS Number:
45127-11-5
Molecular Weight:
282.38
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

mesna

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;/q;2*+1/p-2

InChI key

KQYGMURBTJPBPQ-UHFFFAOYSA-L

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Mesna impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Frederick H Hausheer et al.
Cancer chemotherapy and pharmacology, 52 Suppl 1, S3-15 (2003-06-24)
Any approach applied to drug discovery and development by the medical community and pharmaceutical industry has a direct impact on the future availability of improved, novel, and curative therapies for patients with cancer. By definition, drug discovery is a complex
Dakshine Shanmugarajah et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(10), 857-866 (2009-03-13)
BNP7787 (disodium 2,2'-dithio-bis ethane sulfonate; Tavocept) is a novel water-soluble investigational agent that is undergoing clinical development for prevention and mitigation of cisplatin-induced nephrotoxicity. BNP7787 is a disulfide that undergoes thiol-disulfide exchange reactions in vivo with physiological thiols. Mesna-disulfide heteroconjugates
The effect of cytoprotective agents in platinum anticancer therapy.
Michael A Jakupec et al.
Metal ions in biological systems, 42, 179-208 (2004-06-23)
Supercomputer-designed drug protects against chemotherapy toxicity.
K Senior
The Lancet. Oncology, 1, 198-198 (2002-03-22)
E Boven et al.
European journal of cancer (Oxford, England : 1990), 38(8), 1148-1156 (2002-05-15)
BNP7787 (2',2'-dithio-bis-ethane sulphonate sodium), a water-soluble disulphide, is chemically and mechanistically different from other sulphur-containing chemoprotective agents. Presently, BNP7787 is under investigation for its protective properties with regard to the side-effects of platinum compounds. In this study, we evaluated BNP7787
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