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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

for GC derivatization, LiChropur, ≥98.5%

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
Molecular Weight:
199.25
Beilstein:
1941550
EC Number:
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

Assay

≥98.5% (GC)
≥98.5%

form

liquid

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)
n20/D 1.380

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

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General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylating reagent.

Application

Learn more in the Product Information
MSTFA may be used in silylation procedure to detemine steroid hormones 17α-ethinylestradiol (EE2) and estrone using GC-MS. MSTFA along with Trimethylsilyl chloride (TMCS) in eithyl acetate, acetonitrile and dichloromethane solvents leads to formation of trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) derivatives.
Suitable for the derivatization of amines, amino acids, carboxyl, hydroxyamines, indolalkylamine, n-nitrosoamino acids, nucleosides, phenolalkylamines, serotonin and tryptamine.

Other Notes

Powerful silylating agent
Reagent for N-acetyl-N, trifluoroacetyl, trimethylsilyl, N-trimethylsilyl-N-trifluoroacetyl, and O-trimethylsilyl (TMS)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

77.0 °F - closed cup

Flash Point(C)

25 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Journal of Chromatography A, 115, 591-591 (1975)
M. Donike
Chromatographia, 9, 440-440 (1976)
Hieng-Ming Ting et al.
Frontiers in plant science, 11, 257-257 (2020-03-27)
Glucosinolates are defense-related secondary metabolites found in Brassicaceae. When Brassicaceae come under attack, glucosinolates are hydrolyzed into different forms of glucosinolate hydrolysis products (GHPs). Among the GHPs, isothiocyanates are the most comprehensively characterized defensive compounds, whereas the functional study of
Florence R Danila et al.
Communications biology, 4(1), 254-254 (2021-02-28)
C4 photosynthesis provides an effective solution for overcoming the catalytic inefficiency of Rubisco. The pathway is characterised by a biochemical CO2 concentrating mechanism that operates across mesophyll and bundle sheath (BS) cells and relies on a gas tight BS compartment.

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