MABN79
Anti-BDNF Antibody, clone 8G8.2
clone 8G8.2, from mouse
Synonym(s):
BDNF, Brain-derived neurotrophic factor, Abrineurin
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
8G8.2, monoclonal
species reactivity
mouse
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... BDNF(627)
General description
BDNF is a important neurotrophic factor essential for proper neuronal development and survival of various neuronal populations in the CNS and PNS. BDNF is also key for axonal growth and path finding of dendritic growth and morphology. BDNF also is key to neuronal responses and LTP or LTD and synaptic plasticity, behavior, learning and memory. BDNF is also important in neuronal disease and is being studied as potential marker in various diseases. Finally, BDNF is expressed initially as a proform protein long thought to simply be an inactive proform factor, however recent research demonstrates that proBDNF may play roles not only in neuronal development but also development in general as well as in adult metabolism in brain, muscle, and general metabolic function, so the research into BDNF is growing. BDNF is expressed developmentally in the brain and developing nervous system but it is also expressed in the adult in the brain, gut, muscle, lung, testis, prostate and placenta.
Immunogen
KLH-conjugated linear peptide corresponding to human BDNF.
Application
Anti-BDNF Antibody, clone 8G8.2 is an antibody against BDNF for use in Western Blotting.
Quality
Evaluated by Western Blotting in mouse brain membrane tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected BDNF in 10 µg of mouse brain membrane tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected BDNF in 10 µg of mouse brain membrane tissue lysate.
Target description
~25 kDa observed. UnitProt describes 5 isoforms produced by alternative promoter usage and alternative splicing ranging from 27.8 to 37.1 kDa
Physical form
Format: Purified
Other Notes
Concentration: Please refer to lot specific datasheet.
Not finding the right product?
Try our Product Selector Tool.
recommended
Product No.
Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Karima Schwab et al.
Cells, 10(8) (2021-08-28)
Abnormal aggregation of tau is the pathological hallmark of tauopathies including frontotemporal dementia (FTD). We have generated tau-transgenic mice that express the aggregation-prone P301S human tau (line 66). These mice present with early-onset, high tau load in brain and FTD-like
Yin Zhou et al.
Obesity (Silver Spring, Md.), 26(11), 1749-1757 (2018-10-26)
This study aimed to determine the effects of diet-induced paternal obesity on cognitive function in mice offspring. Male mice (F0) were randomized to receive either a control diet (10 kcal% fat) or a high-fat diet (HFD; 60 kcal% fat) for
Cong Duc Nguyen et al.
Drug delivery, 29(1), 2855-2867 (2022-09-07)
Much research has shown Bee venom to be an effective neuroprotective agent. However, the usual transdermal injection of bee venom poses many pharmacokinetic disadvantages. Here, we compared the administration of bee venom via subcutaneous injection (SC) and via Microneedle patch
Zhi-Chi Chen et al.
CNS neuroscience & therapeutics, 26(10), 1069-1082 (2020-07-01)
It has been reported that allopregnanolone (APα) promotes the neurogenesis of the neural progenitor cells (NPCs) in the subventricular zone (SVZ) and prevents the decrease of dopaminergic neurons in 6-hydroxydopamine (6-OHDA)-treated mice by binding to γ-aminobutyric acid A receptor (GABAAR)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service