M04S-03-5PK
CellASIC ONIX switching plate mammalian cells (4 chamber)
The M04 switching plates enable continuous perfusion culture for live cell analysis. Laminar flow provides rapid & uniform solution exchange for maximum cell health. The glass coverslide bottom surface ensures the highest resolution optical viewing.
Synonym(s):
CellASIC ONIX Plate, Mammalian Cell Plate, ONIX Switching Plate
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About This Item
UNSPSC Code:
41104923
eCl@ss:
32011202
NACRES:
NB.22
Recommended Products
material
PMMA
glass
polycarbonate
polydimethylsiloxane (PDMS)
manufacturer/tradename
CellASIC® ONIX
W × L × H
85.48 mm × 127.76 mm × 14.35 mm
compatibility
for use with cells sized up to 50.0 μm
shipped in
ambient
General description
CellASIC® ONIX switching plate mammalian cells (4 chambers) enable continuous perfusion culture for live cell analysis. Laminar flow provides a rapid and uniform solution exchange for maximum cell health. The glass cover slide bottom surface ensures the highest resolution of optical viewing.
Application
CellASIC® ONIX switching plate mammalian cells(4 chambers) have been used:
- in live-cell imaging to study the contribution of phi-particle in the autoinhibition of dynein and the activation of dynein by dynactin
- in live-cell imaging of fcSAgA binding and immunoglobulin M surface clustering by fluorescence microscopy
- in multiple epidermal growth factor (EGF)pulse experiments
- time-lapse analysis of adherent cells
- long-term continuous perfusion experiments (3 days typical)
- solution exchange experiments (induction, inhibition, drug dosing, etc.)
- automated immunostaining and on-demand fixation of live cells within the culture chamber
- comparison of up to four different cell types or exposure conditions (media components) in parallel, temperature, and gas atmospheric control (temperature shift, anoxic conditions, etc.)
Features and Benefits
- Compatible with CellASIC® ONIX2 Microfluidic system and ONIX2 Manifolds
- Enables perfusion-based, long-term, live-cell analysis with solution switching
- The plate offers a controlled and dynamic microenvironment for 2D and 3D cell cultures
Legal Information
CELLASIC is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Brittany L Hartwell et al.
Biomacromolecules, 18(6), 1893-1907 (2017-05-06)
A pressing need exists for antigen-specific immunotherapies (ASIT) that induce selective tolerance in autoimmune disease while avoiding deleterious global immunosuppression. Multivalent soluble antigen arrays (SAgAPLP:LABL), consisting of a hyaluronic acid (HA) linear polymer backbone cografted with multiple copies of autoantigen
Kai Zhang et al.
Cell, 169(7), 1303-1314 (2017-06-13)
Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we
Angel Stanoev et al.
Cell systems, 7(3), 295-309 (2018-08-27)
The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose sensitivity to growth factors and signal duration determines cellular behavior. We resolve how EGFR's response to epidermal growth factor (EGF) originates from dynamically established recursive interactions with spatially
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