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Oxotremorine M

Name: Oxotremorine M
Brand: SIGMA

muscarinic acetylcholine receptor agonist, solid

Synonym(s):

N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide, Oxotremorine methiodide

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₉IN₂O

CAS Number:

63939-65-1

Molecular Weight:

322.19

UNSPSC Code:

12352200

PubChem Substance ID:

24277861

NACRES:

NA.77

MDL number:

MFCD00055133

Form:

solid

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Properties

Product Name

Oxotremorine M, solid

form

solid

Quality Segment

200

color

white

solubility

H₂O: 24 mg/mL, ethanol: 4.6 mg/mL

storage temp.

2-8°C

SMILES string

[I-].C[N+](C)(C)CC#CCN1CCCC1=O

InChI

1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1

InChI key

VVLMSCJCXMBGDI-UHFFFAOYSA-M

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Application

Oxotremorine M has been used as a muscarinic acetylcholine receptor (mAchR) agonist:

to study its acute effects on the movement of Caenorhabditis elegans
to treat hippocampal neurons for studying fibroblast growth factor receptor 1 (FGFR1) phosphorylation
to induce bladder overactivity in rats

Biochem/physiol Actions

Oxotremorine M is a nonselective muscarinic acetylcholine receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) and Acetylcholine Receptors (Nicotinic) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	SML0787	SML0243	SML0990
Sigma-Aldrich O100 Oxotremorine M	Sigma-Aldrich SML0787 AC 42	Sigma-Aldrich SML0243 ML169	Sigma-Aldrich SML0990 JW651
description solid	description ≥98% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC)
form solid	form powder	form powder	form powder
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: 24 mg/mL, ethanol: 4.6 mg/mL	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: >5 mg/mL	solubility DMSO: 10 mg/mL, clear
color white	color white to beige	color white to beige	color white to beige
Gene Information human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)	Gene Information -	Gene Information -	Gene Information -

Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H300 + H310 + H330

Precautionary Statements

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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