HPA038515
Anti-PRG2 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-BMPG, Anti-MBP, Anti-Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
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About This Item
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:500-1:1000
immunogen sequence
GSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRC
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRG2(5553)
General description
PRG2 (proteoglycan 2, pro eosinophil major basic protein)/ major basic protein (MBP) is a cationic protein of human eosinophil specific granules, that is present in crystalloid cores of these granules. MBP is a helminthotoxin. PRG2 is mapped to human chromosome 11q12.
Immunogen
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-PRG2 antibody produced in rabbit has been used in immunohistochemistry.
Anti-PRG2 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Eosinophils are white blood cells, which play a major role in innate immunity and in the pathogenesis of several inflammatory and neoplastic disorders. Accumulation of PRG2 (proteoglycan 2, pro eosinophil major basic protein)/ major basic protein (MBP) impairs epithelial cells in vitro, in vivo and ex vivo. It plays an important role in mediating cytotoxicity and allergic disorders like asthma. PRG2 helps to enhance smooth muscle reactivity by affecting vagal muscarinic M2 receptor, that helps in the progression of airway hyperreactivity.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST80814
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.
Soragni A, et al.
Molecular Cell, 57(6), 1011-1021 (2015)
Functional copy number changes in Sezary syndrome: toward an integrated molecular cytogenetic map III.
Mao X and McElwaine S
Cancer Genetics and Cytogenetics, 185(2), 86-94 (2008)
Elisa T Zhang et al.
Biology of reproduction, 105(1), 244-257 (2021-05-14)
The obstetrical conditions placenta accreta spectrum (PAS) and placenta previa are a significant source of pregnancy-associated morbidity and mortality, yet the specific molecular and cellular underpinnings of these conditions are not known. In this study, we identified misregulated gene expression
Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells.
Seebauer CT, et al.
Oncoimmunology, 5(12), e1242543-e1242543 (2016)
Vesicle-mediated secretion of human eosinophil granule-derived major basic protein.
Melo RCN, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 89(7), 769-769 (2009)
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