39488

Pyrimidine nucleoside phosphorylase

recombinant, expressed in E. coli, ≥1300 U/mL

• CAS Number: 9055-35-0
• MDL number: MFCD00011685
• UNSPSC Code: 12352204
• NACRES: NA.54
• EC Number: 2.4.2.2 (BRENDA, IUBMB)
• Specific activity: ≥1300 U/mL
• Recombinant: expressed in E. coli

Properties

• recombinant: expressed in E. coli
• Quality Segment: 100
• form: liquid
• specific activity: ≥1300 U/mL
• relevant disease(s): cancer
• storage temp.: −20°C

Description

Application

Pyrimidine nucleoside phosphorylase (PyNPase) may be used as a marker to predict the malignant potential of breast cancer, especially lymph node metastasis. PyNPase is used to study breast cancer, specifically its role in angiogenesis.

Biochem/physiol Actions

Pyrimidine nucleoside phosphorylase (PyNPase) is a glycosyltransferase that catalyzes the conversion of pyrimidine nucleoside and phosphate to a pyrimidine base and α-D-ribose 1-phosphate. PyNPase plays a significant role in breast cancer angiogenesis.

Other Notes

One unit will convert 1 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per minute at pH 7.4 and 25°C

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H334
• pcodes: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable