D6924

Dextran sulfate sodium salt from Leuconostoc spp.

average mol wt 9,000-20,000

• CAS Number: 9011-18-1
• MDL number: MFCD00081551
• UNSPSC Code: 12352201
• NACRES: NA.21

Properties

• biological source: bacterial (Leuconostoc mesenteroides)
• Quality Level: 200
• form: powder
• optical activity: [α]/D 90 to 105 °, c = 6% (w/v)
• mol wt: average mol wt 9,000-20,000
• composition: Sulfur Content, 16.0-19.0%
• color: white to off-white
• useful pH range: 5.5 - 8.0
• solubility: H₂O: 100 mg/mL
• storage temp.: room temp

Description

General description

Dextran sulfate sodium is a natural polymer of α-1,6-D-glucopyranose. It is a hydrophilic, biodegradable, and biocompatible polyanionic polymer. This highly branched polysaccharide has 1,6 and 1,4 glycosidic linkages, consisting of 2.3 sulfate groups per glucosyl unit.

Application

Dextran sulfate sodium salt from Leuconostoc spp. has been used:

• to evaluate the participation of sulfated glycans on the interaction of recombinant human proacrosin/acrosin with zona pellucida (ZP) glycoproteins
• to inject into the vitreous cavity of embryonic day five chick embryos to assess the eye size and to study its impact on cell proliferation in the retina
• to test the structural specificity of binding of TNF-stimulated gene 6 (TSG-6) to immobilized hyaluronan (HA)

Biochem/physiol Actions

Dextran sulfate may exhibit anti-coagulant and antiviral properties. It may also help to lower cholesterol levels. It is extensively used as a plasma volume expander and fibrinolytic in the medical field. Dextran sulfate can also be used as a cross-linker for chitosan (CH).

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves