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97151

Supelco

Hederacoside C

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C59H96O26
CAS Number:
14216-03-6
Molecular Weight:
1221.38
Beilstein:
4229541
EC Number:
238-072-2
MDL number:
MFCD00198062
UNSPSC Code:
85151701
PubChem Substance ID:
329770354
NACRES:
NA.24
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

222 °C (dec.) (lit.)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12CC=C3C4CC(C)(C)CC[C@@]4(CC[C@@]3(C)[C@]1(C)CCC5[C@](C)(CO)[C@H](CC[C@]25C)O[C@@H]6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H](C)[C@H](O)[C@@H](O)[C@H]7O)C(=O)O[C@@H]8O[C@H](CO[C@@H]9O[C@H](CO)[C@@H](O[C@@H]%10O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@@H](O)[C@H](O)[C@H]8O

InChI

1S/C59H96O26/c1-24-34(63)38(67)42(71)49(78-24)83-46-29(20-60)80-48(45(74)41(46)70)77-22-30-37(66)40(69)44(73)51(81-30)85-53(75)59-17-15-54(3,4)19-27(59)26-9-10-32-55(5)13-12-33(56(6,23-61)31(55)11-14-58(32,8)57(26,7)16-18-59)82-52-47(36(65)28(62)21-76-52)84-50-43(72)39(68)35(64)25(2)79-50/h9,24-25,27-52,60-74H,10-23H2,1-8H3/t24-,25-,27?,28-,29+,30+,31?,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56-,57+,58+,59-/m0/s1

InChI key

RYHDIBJJJRNDSX-WBOYGZCJSA-N

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General description

Hederacoside C is a natural triterpenoid saponin. It is the primary bioactive ingredient of traditional Chinese herbal medicines, isolated from Hedera helix, also known as common ivy or English ivy. It is known for its expectorant, bronchodilator, antibacterial, and bronchospasmolytic properties in the treatment of respiratory disorders.[1][2][1]

Application

This analytical standard can also be used as follows:
  • Development of a bioanalytical method to measure hederacoside c in rat plasma samples by ultra high-performance liquid chromatographic-tandem mass spectrometric (UPLC-MS/MS) method
  • Simultaneous analysis of six natural compounds isolated from ivy leaf extract samples by UHPLC coupled with electrospray ionization-triple quadrupole mass spectrometeric (ESI-MS/MS) detection
  • Ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC‐Q‐TOF‐MS/MS) based phytochemical profiling of Hedera helix for pharmaceutical applications

Packaging

Bottomless glass bottle. The content inside is inserted in a fused cone.

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM1379
BCCL6425
BCCJ6803
BCCK2640
BCCL0676

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A validated RP HPLC-PAD method for the determination of hederacoside C in Ivy-Thyme cough syrup
Khdair A, et al.
International Journal of Analytical Chemistry (2010)
Determination of saponins and flavonoids in ivy leaf extracts using HPLC-DA
Yu M, et al.
Journal of Chromatographic Science, 53(4), 478-483 (2014)
Jongwon Choi et al.
Journal of ethnopharmacology, 79(1), 113-118 (2001-12-18)
The stem bark of Kalopanax pictus is an anti-rheumatoidal arthritis drug in Oriental medicine. In the rheumatoidal rat, induced by Freund's complete adjuvant (FCA) reagent, we investigated the effects of hederagenin monodesmosides of K. pictus on oxidative stress and hepatic
W J Sun et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 25(1), 29-34 (1990-01-01)
Two crystalline components I and II were isolated from the total saponin of Kalopanax septemlobus (Thunb.) koidz. Crystalline II was identified as kalopanax saponin A and I was named as Kalopanax saponin C and eluciated as 3-O-[alpha-L-rhamnopyranosyl-(1----2)-alpha-L-arabinopyranosyl]- hedragenin-28-[alpha-L-rhamnopyranosyl-(1----2)- beta-D-glucopyranosyl (1----6)-beta-D-glucopyransyl]ester
Jongwon Choi et al.
Journal of ethnopharmacology, 79(2), 199-204 (2002-01-22)
In the present study, we have attempted to elucidate the active components for rheumatoidal arthritis using chloroform (CHCl(3)), ethylacetate (EtOAc) and n-butanol (BuOH) fractions of the methanol extract (MeOH) of Kalopanax pictus. Kalopanaxsaponin-A and -I (KPS-A and -I, hederagenin monodesmoside)
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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