907197

1,4-Dinitro-1-imidazole

• Synonym(s): 1,4-DNIm, 1,4-Dinitroimidazole, Bifunctional bioconjugation reagent
• Empirical Formula (Hill Notation): C₃H₂N₄O₄
• CAS Number: 19182-81-1
• Molecular Weight: 158.07
• MDL number: MFCD00297235
• UNSPSC Code: 12352005

Properties

• Assay: ≥95%
• form: solid
• storage temp.: −20°C
• InChI: 1S/C3H2N4O4/c8-6(9)3-1-5(2-4-3)7(10)11/h1-2H
• InChI key: HZPSREFSUPXCMN-UHFFFAOYSA-N

Description

Application

1,4-Dinitro-1-imidazole (1,4-DNIm) and other dinitroimidazoles were demonstrated to be bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. In acidic to neutral aqueous conditions, 1,4-DNIms chemoselectively react with cysteines; in organic solvents in the presence of base, 1,4-DNIms chemoselectively react with lysines to form stable conjugates

Other Notes

Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable