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T8931

Sigma-Aldrich

Thyrotropic hormone from bovine pituitary

Synonym(s):

TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands

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About This Item

CAS Number:
9002-71-5
MDL number:
MFCD00166060
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

bovine pituitary glands

Quality Level

200

form

powder

packaging

vial of 100 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01223
P16473

storage temp.

2-8°C

Gene Information

cow ... TSHB(281552)
human ... TSHR(7253)

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General description

Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.

Application

Thyrotropic hormone from bovine pituitary has been used:
  • to induce cAMP production in orbital fibroblasts.
  • as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
  • for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
  • for studying the thyrotropin involvement in photoperiodic signal transduction in mice.

Biochem/physiol Actions

Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Quality

Contains phosphate buffer salts

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
Pituitary, Thyroid, and Parathyroid Pharmacology
Galasko GT
Pharmacology and Therapeutics for Dentistry, 417-428 (2017)
A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy
Turcu AF, et al.
The Journal of Clinical Endocrinology and Metabolism, 98(5), 2153-2159 (2013)
Roberto Rocchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(14), 6019-6024 (2007-03-29)
Bacterial infections and other pathologic conditions induce complex dysfunctions of the hypothalamic-pituitary-thyroid axis, collectively known as nonthyroidal illness (NTI). To explore the pathogenesis of bacterial NTI, we injected Mycobacterium tuberculosis extracts or Escherichia coli LPS in mice lacking key components
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma
Lal G, et al.
Cancer, 107(12), 2752-2759 (2006)
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