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Key Documents

SAB4501438

Sigma-Aldrich

Anti-APC antibody produced in rabbit

affinity isolated antibody

Synonym(s):

APC, APC protein, Adenomatous polyposis coli protein, DP2.5, adenomatous polyposis of the colon gene

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 311 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P25054

UniProt accession no.

P25054

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APC(324)

General description

Adenomatous polyposis coli (APC) is a tumour suppressor gene. It is located on human chromosome 5q21.
Anti-APC Antibody detects endogenous levels of total APC protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human APC.

Immunogen Range: 2794-2843

Biochem/physiol Actions

Adenomatous polyposis coli (APC) plays an important role in cell division, adhesion and migration. Mutations in APC gene is associated with colorectal carcinomas.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Epigenetic regulation of APC in the molecular pathogenesis of gallbladder cancer
Tekcham DS, et al.
The Indian Journal of Medical Research, 143(Suppl 1) (2016)
Adenomatous polyposis coli (APC) regulates miR17-92 cluster through ?-catenin pathway in colorectal cancer.
Li Y
Oncogene, 35(35), 4558-4568 (2016)
Lorenzo Alibardi
Journal of morphology, 283(5), 677-688 (2022-02-24)
Lizard tail regeneration is likely regulated by the balanced activity of oncogenes and tumor suppressors that control cell proliferation avoiding tumorigenic degeneration. One of the main tumor suppressor genes present in the regenerating tail is the "adenomatous polyposis coli (apc)"
Till Ringel et al.
Cell stem cell, 26(3), 431-440 (2020-03-07)
Forward genetic screens with genome-wide CRISPR libraries are powerful tools for resolving cellular circuits and signaling pathways. Applying this technology to organoids, however, has been hampered by technical limitations. Here we report improved accuracy and robustness for pooled-library CRISPR screens by
Hongfei Ge et al.
Molecular neurobiology (2021-10-13)
Spinal cord injury (SCI), a devastating neurological impairment, usually imposes a long-term psychological stress and high socioeconomic burden for the sufferers and their family. Recent researchers have paid arousing attention to white matter injury and the underlying mechanism following SCI.

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