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Key Documents

SAB2501063

Sigma-Aldrich

Anti-TROP2 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-EGP-1, Anti-GA733, Anti-GA733-1, Anti-TACSTD2, Anti-Tumor-associated calcium signal transducer 2

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About This Item

MDL number:
MFCD03456064
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ELISA: suitable
western blot: suitable

UniProt accession no.

P09758

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TACSTD2(4070)

General description

Tumor associated calcium signal transducer 2 (TACSTD2), also known as trophoblast cell surface antigen 2 (TROP2), is a 36 kDa protein and part of the TACSTD family. The gene encoding this cell surface glycoprotein is localized on human chromosome 1p32.1.

Immunogen

Peptide with sequence C-HYEQPTIQIELRQN from the internal region of the protein sequence according to NP_002344.2.

Biochem/physiol Actions

Trophoblast cell surface antigen 2 (TROP2) has a role in epithelial-mesenchymal transition. It modulates stem cell activity and is crucial in promoting cell self-renewal and survival. TROP2 increases intracellular calcium levels. The protein is overexpressed in many cancers. It has been shown to influence the proliferation and migration of gallbladder cancer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease.
Liu Q, et al.
Respiratory Research, 17(1), 159-159 (2016)
TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT.
Li X, et al.
Oncotarget, 8(29), 47052-47052 (2017)
Overexpression of trophoblast cell surface antigen 2 as an independent marker for a poor prognosis and as a potential therapeutic target in epithelial ovarian carcinoma.
Xu N,et al.
International Journal of Experimental Pathology, 97(2), 150-158 (2016)
TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity.
Fong D, et al.
Modern Pathology, 21(2), 186-186 (2008)

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