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Key Documents

S6942

Sigma-Aldrich

Staurosporine

from Streptomyces sp., >98% (HPLC), solution, protein kinase inhibitor

Synonym(s):

Antibiotic AM-2282

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About This Item

EC Number:
200-664-3
MDL number:
MFCD04041131
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL), 0.2 μm filtered

Quality Level

300

sterility

0.2 μm filtered

Assay

>98% (HPLC)

concentration

1 mM in DMSO (100 μg/214 μL)

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

fungi

Mode of action

enzyme | inhibits

shipped in

wet ice

storage temp.

−20°C

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General description

Chemical structure: indol derivative

Application

Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4

Biochem/physiol Actions

Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yu-Jung Lee et al.
American journal of physiology. Renal physiology, 292(1), F340-F350 (2006-08-10)
Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two
Jan Roger Olsen et al.
PloS one, 8(5), e62547-e62547 (2013-05-10)
The transcription factor p63 is central for epithelial homeostasis and development. In our model of epithelial to mesenchymal transition (EMT) in human prostate cells, p63 was one of the most down-regulated transcription factors during EMT. We therefore investigated the role
Suainibhe Kelly et al.
Nanoscale, 13(41), 17615-17628 (2021-10-19)
The use of nanomaterials as therapeutic delivery vehicles requires their careful pre-clinical evaluation. Of particular importance in this regard is measurement of cellular toxicity, ideally assessing multiple parameters in parallel from various relevant subcellular organelles. In recent years it has
Marije B Overdijk et al.
Molecular cancer therapeutics, 19(10), 2126-2138 (2020-08-28)
Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however, therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe HexaBody-DR5/DR5, an equimolar mixture of two DR5-specific IgG1 antibodies with an Fc-domain mutation that augments antibody hexamerization
T Christopher Windham et al.
Oncogene, 21(51), 7797-7807 (2002-11-07)
Src is a non-receptor protein tyrosine kinase, the expression and activity of which is increased in >80% of human colon cancers with respect to normal colonic epithelium. Previous studies from this and other laboratories have demonstrated that Src activity contributes
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