P1742
Prealbumin from human plasma
lyophilized powder
Synonym(s):
Thyroxine binding prealbumin, Transthyretin
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About This Item
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biological source
human plasma
Quality Level
Assay
≥95% (SDS-PAGE)
form
lyophilized powder
technique(s)
immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable
solubility
H2O: soluble 1 mg/mL
ε (extinction coefficient)
13.5 at 280 nm at 1%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TTR(7276)
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General description
Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver. It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.
Application
Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.
Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.
Biochem/physiol Actions
Human prealbumin has been observed in carcinoid tumors.
Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing sodium phosphate and NaCl
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Prealbumin is as important as albumin in the nutritional assessment of hemodialysis patients
Chertow GM, et al.
Kidney International, 58(6), 2512-2517 (2000)
K Nelson et al.
International journal of cancer, 15(5), 806-814 (1975-05-15)
Spleen cells from BALB/c mice which either bore syngeneic sarcomas or were normal controls were cultured in vitro. The culture supernatants of spleen cells from tumor-bearing mice inhibited (blocked) specific cell-mediated cytotoxicity to the tumor borne by the spleen donor.
Haruki Koike et al.
Journal of neurology, 255(10), 1526-1533 (2008-09-30)
Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed. To examine the electrophysiological features of late-onset FAP TTR Met30 unrelated to endemic
David Adams et al.
Presse medicale (Paris, France : 1983), 41(9 Pt 1), 793-806 (2012-02-22)
The treatment of familial amyloid polyneuropathies (FAP) is complex and requires a neurological and cardiological multidisciplinary coverage. It includes specific treatments to control the progression of the systemic amyloidogenesis, the symptomatic treatment of the peripheral and autonomic neuropathy (digestive, urinary
J P Hegmann
Behavior genetics, 9(3), 165-175 (1979-05-01)
Behavioral and physiological scores from 697 mice sampled from lines at various times during their response to bidirectional selection for divergent caudal nerve conduction velocity suggest broad-reaching behavioral effects of the gene differences among lines. Sciatic nerve conduction velocity differences
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