M4199
Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse
lyophilized powder
Synonym(s):
MOG (40-54)
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About This Item
Empirical Formula (Hill Notation):
C84H127N27O21
CAS Number:
Molecular Weight:
1851.08
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
biological source
rat
Quality Level
Assay
≥97% (HPLC)
form
lyophilized powder
color
white
solubility
deionized water: soluble
storage temp.
−20°C
Gene Information
mouse ... Mog(17441)
rat ... Mog(24558)
Amino Acid Sequence
Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly
Biochem/physiol Actions
The 21-residue peptide MOG 35-55 contains an antigenic epitope responsible for the activation of CD8 encephalitogenic T cells in mice. Two truncated peptides, MOG 40-54 and MOG 44-54 were shown to bind the recombinant H-2Db protein. This complex then binds MOG specific CD8 T cells. While MOG 40-54 retained the full capability of inducing paralytic disease, MOG 44-54 only partialy causes clinical paralysis and central nervous system inflamation.
Physical form
Lyophilized from 0.1% aqueous TFA.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption.
Okamoto H
Neuroscience Letters (2006)
Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice
Cecile Delarasse
Immunology (2013)
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