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recombinant
expressed in E. coli
Quality Level
Assay
≥80% (SDS-PAGE)
form
solution
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−70°C
Application
S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors . MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness .
Biochem/physiol Actions
MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation .
Physical properties
N-terminal GST-tagged 57 kDa protein containing amino acids 2-end.
Physical form
Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween®-20, 10% glycerol,and 3 mM DTT.
Legal Information
TWEEN is a registered trademark of Croda International PLC
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Zarah Glad Zimling et al.
Histopathology, 60(6B), E96-105 (2012-03-08)
Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and
Shasha Li et al.
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 14(2), 151-155 (2011-02-24)
The abnormal expression of MTAP, a tumor suppressor gene, is found in a variety of tumor tissues. The aim of this study is to detect the expression of MTAP mRNA protein and the clinical significance for the therapy of non-small
Hsuan-Ying Huang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(22), 6963-6972 (2009-11-06)
Chromosome 9 is frequently deleted in high-risk gastrointestinal stromal tumors (GISTs), whereas its specific tumor suppressor genes (TSGs) are less understood. We did an integrative study of MTAP gene at 9p21 to analyze its implication in GISTs. To search TSGs
Giovanna Cacciapuoti et al.
Biochimica et biophysica acta, 1814(10), 1358-1366 (2011-06-21)
Purine nucleoside metabolism in the archaeon Pyrococcus furiosus is catalyzed by purine nucleoside phosphorylase (PfPNP) and 5'-deoxy-5'-methylthioadenosine phosphorylase (PfMTAP). These enzymes, characterized by 50% amino acid sequence identity, show non-common features of thermophilicity and thermostability and are stabilized by intramolecular
Olga Camacho-Vanegas et al.
American journal of human genetics, 90(4), 614-627 (2012-04-03)
Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMS-MFH) is an autosomal-dominant syndrome characterized by bone dysplasia, myopathy, and bone cancer. We previously mapped the DMS-MFH tumor-suppressing-gene locus to chromosomal region 9p21-22 but failed to identify mutations in known genes in
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