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Key Documents

L5900

Sigma-Aldrich

Linoleic Acid-Water Soluble

powder, BioReagent, suitable for cell culture

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.75

biological source

plant (Safflower oil)

Quality Level

200

product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 50 mg/mL

storage temp.

−20°C

Application

Linoleic acid-water soluble has been used as a component of fatting media for the in vitro steatosis induction of primary human hepatocytes (PHH).

Biochem/physiol Actions

Linoleic acid (LA) is an arachidonic acid precursor, which is present in vegetable oils. It enhances wound healing in diabetic rats. LA triggers tumor and apoptosis in colorectal cancer cells. The levels of LA in adipose tissue and platelets are associated with coronary artery disease. Linoleic acid binds to molecules, such as bovine serum albumin (BSA) or cyclodextrin for use in cell culture.

Other Notes

Contains approx. 30 mg of linoleic acid per gram; balance methyl-β-cyclodextrin.
Package size based on linoleic acid content.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells
Pei F, et al.
Stem Cell Research, 19, 94-103 (2017)
Linoleic acid: a nutritional quandary
Jandacek RJ
Healthcare (Basel, Switzerland) , 5(2), 25-25 (2017)
Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis
DiNicolantonio JJ and O?Keefe JH
Open heart, 5(2), e000898-e000898 (2018)
Enhancement effects of BSA and linoleic acid on hybridoma cell growth and antibody production
Cell Culture Engineering IV, 51-56 (1994)
An overview of the effect of linoleic and conjugated-linoleic acids on the growth of several human tumor cell lines
Maggiora M, et al.
International Journal of Cancer. Journal International Du Cancer, 112(6), 909-919 (2004)
View All Related Papers

Articles

Linoleic acid in Cell Culture

Importance and uses of linoleic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Oleic Acid in Cell Culture

How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.

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