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Key Documents

H5534

Sigma-Aldrich

trans-4-Hydroxy-L-proline

≥98.5%, suitable for cell culture, BioReagent

Synonym(s):

4-Hydroxyproline, Hydroxyproline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp

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About This Item

Empirical Formula (Hill Notation):
C5H9NO3
CAS Number:
Molecular Weight:
131.13
Beilstein:
81441
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

trans-4-Hydroxy-L-proline, BioReagent, suitable for cell culture, ≥98.5%

product line

BioReagent

Quality Level

Assay

≥98.5%

form

crystalline

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless

mp

273 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

application(s)

peptide synthesis

SMILES string

O[C@H]1CN[C@@H](C1)C(O)=O

InChI

1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

InChI key

PMMYEEVYMWASQN-DMTCNVIQSA-N

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Application


  • Cysteine Radical and Glutamate Collaboratively Enable C-H Bond Activation and C-N Bond Cleavage in a Glycyl Radical Enzyme HplG.: This research showcases the application of trans-4-hydroxy-L-proline in studying enzymatic reactions that involve C-H bond activation and C-N bond cleavage, providing insights into the mechanisms of enzymatic control and specificity which are essential for the development of novel biochemical processes (Deng and Liao, 2024).

  • Study on flavor quality formation in green and yellow tea processing by means of UPLC-MS approach.: Utilizing trans-4-hydroxy-L-proline, this study enhances the understanding of flavor biochemistry in tea processing, offering significant insights into the food chemistry sector and influencing future product development strategies (Sun et al., 2024).


Other Notes

Natural constituent of animal structural proteins such as collagen and elastin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proline and hydroxyproline metabolism: implications for animal and human nutrition
Guoyao Wu
Amino Acids, 40{4}, 1053-1063 (2011)
Biochemical Markers of Bone Turnover Part I: Biochemistry and Variability
Biochemical Markers of Bone Turnover Part I: Markus J Markus J Seibel
The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists, 26(4), 97-122 (2005)
Lodish H
Molecular Cell Biology (2000)
Overexpression of Latent TGF? Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGF?
Kay-Marie Lamar
PLoS Genetics, 1-23 (2016)
Effect of Function-Enhanced Mesenchymal Stem Cells Infected With Decorin-Expressing Adenovirus on Hepatic Fibrosis
Jang Yoon O
Stem Cells Translational Medicine, 5, 1247-1256 (2016)

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