G4923

(E)-Guggulsterone

≥95% (HPLC), powder

• Synonym(s): (17E)-Pregna-4,17(20)-diene-3,16-dione
• Empirical Formula (Hill Notation): C₂₁H₂₈O₂
• CAS Number: 39025-24-6
• Molecular Weight: 312.45
• MDL number: MFCD01310758
• UNSPSC Code: 12352205
• PubChem Substance ID: 329799934
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: soluble 5 mg/mL
• functional group: ketone
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: C\C=C1\C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4-/t15-,17+,18+,20+,21-/m1/s1
• InChI key: WDXRGPWQVHZTQJ-AUKWTSKRSA-N

Description

Biochem/physiol Actions

Naturally occuring bioactive plant sterol isolated from the gum resin of guggul (Commiphora wightii). Antihyperlipidemic. Induces the expression of human CYP3A.. Guggulsterone potently reverses multi-drug resistance in a number of human cancer cell lines, extending the efficacy of chemotherapy.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H335,H412
• Precautionary Statements: P261 - P271 - P273 - P304 + P340 + P312 - P403 + P233 - P405
• Hazard Classifications: Aquatic Chronic 3 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable