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About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
97%
form
solid
SMILES string
NC(=S)NC(N)=S
InChI
1S/C2H5N3S2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)
InChI key
JIRRNZWTWJGJCT-UHFFFAOYSA-N
General description
Paralytic agent.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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W D Atchison
The Journal of pharmacology and experimental therapeutics, 249(3), 735-743 (1989-06-01)
Daily treatment of rats with 2,4-dithiobiuret (DTB, 1 mg/kg/day i.p.) produces a flaccid neuromuscular weakness first observed in the hindlimbs after 5 to 6 days of treatment. This condition is characterized by diminished contractile strength following single shock and tetanic
W R Porter et al.
Neurotoxicology, 4(4), 57-68 (1983-01-01)
[14C] Dithiobiuret (DTB)-derived radioactivity is eliminated by adult male rats with an approximate plasma half-life of 8-10 hr. About 65-75% of an i.p. dose appears in the urine within 24 hr after treatment and about 2-4% appears in the feces
W D Atchison
Toxicology and applied pharmacology, 106(2), 234-244 (1990-11-01)
Daily treatment of rats with 2,4-dithiobiuret (DTB, 1 mg/kg/day, ip) causes a flaccid neuromuscular weakness first observable in the hindlimbs after 5-6 days of treatment. With continued exposure, neuromuscular weakness appears to encompass the other muscles of the body; death
K D Williams et al.
Neurotoxicology, 3(4), 221-231 (1982-12-01)
Our main objective was to describe the metabolism of dithiobiuret (DTB) in the adult, male rat. Based on the thin-layer chromatographic analysis of urine from animals treated ip with 1 mg/kg of [14C] or [35S] labeled DTB, two pathways for
K D Williams et al.
Neurotoxicology, 7(1), 33-49 (1986-01-01)
Daily administration of dithiobiuret (DTB, 1 mg/kg X 6 days, ip) produced delayed onset muscle weakness in rats as indicated by failure in a treadmill test. In nerve-muscle preparations from DTB-intoxicated rats neuromuscular toxicity was manifested as contractile fatigue during
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