C4124
Chromium picolinate
≥98% (HPLC)
Synonym(s):
Cr(pic)3, CrPic
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About This Item
Empirical Formula (Hill Notation):
C18H12CrN3O6
CAS Number:
Molecular Weight:
418.30
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
Assay:
≥98% (HPLC)
form:
powder
Recommended Products
biological source
synthetic
Quality Level
Assay
≥98% (HPLC)
form
powder
loss
≤5% loss on drying
storage temp.
room temp
SMILES string
O=C(O[Cr](OC(=O)c1ccccn1)OC(=O)c2ccccn2)c3ccccn3
InChI
1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3
InChI key
CBDQOLKNTOMMTL-UHFFFAOYSA-K
General description
Chromium picolinate is a supplemental or alternative medication for type 2 diabetes and an anti-diabetic mechanisms of CrPic in insulin-resistant 3T3-L1 adipocytes.
Application
Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.
Biochem/physiol Actions
Chromium picolinate (CrPic) is a supplemental or alternative medication for type 2 diabetes. Experimental evidence shows the effect of CrPic on glucose uptake through the activation of p38 MAPK. Chromium is thought to potentiate the action of insulin, leading to increased insulin sensitivity in type 2 diabetes.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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J L G van de Ligt et al.
Journal of animal science, 80(2), 449-455 (2002-03-09)
A total of 60 pigs from 15 litters were used during two experiments to assess the effects of maternal supplementation of Cr tripicolinate on performance and immune status of the offspring during the first 42 d after weaning. Gilts were
M D Lindemann et al.
Journal of animal science, 86(11), 2971-2978 (2008-07-05)
The concentration of Cr in several tissues in response to high-level, short-term supplementation was used to determine the relative bioavailability among 4 organic Cr sources and to assess the relative safety of high levels of supplementation. Crossbred pigs (n =
C P A van de Ligt et al.
Journal of animal science, 80(2), 483-493 (2002-03-09)
Two experiments were conducted to evaluate potential interactive effects of supplemental Cr and dietary energy supply in growing pigs. Experiment 1 used 36 individually penned barrows, 25 to 65 kg, in a 2 x 3 factorial arrangement of supplemental Cr
J C Woodworth et al.
Domestic animal endocrinology, 26(1), 1-9 (2004-01-21)
Thirty-four sows (parity=1.8; BW=206 kg) were used to determine the influence of L-carnitine and/or chromium tripicolinate on plasma leptin concentrations of gestating sows fed one meal daily. Treatments were arranged in a 2 x 2 factorial with main effects of
G W Evans et al.
Journal of inorganic biochemistry, 49(3), 177-187 (1993-02-15)
Coordination complexes of chromium (Cr) and two pyridine carboxylate isomers, nicotinate (nic) and picolinate (pic) were synthesized and analyzed. Cr mono and dinicotinate complexes were formed with 1:1 and 1:2 ratios of Cr3+ and nic at pH 7.5. Cr dinicotinate
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