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A5880

Sigma-Aldrich

D-Amphetamine hemisulfate salt

Synonym(s):

(+)-α-Methylphenethylamine hemisulfate salt, Dextroamphetamine hemisulfate salt

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About This Item

Empirical Formula (Hill Notation):
C9H13N · 0.5 H2SO4
CAS Number:
51-63-8
Molecular Weight:
184.25
EC Number:
200-111-6
MDL number:
MFCD00069209
UNSPSC Code:
12352116
PubChem Substance ID:
24891028
NACRES:
NA.77

form

powder

Quality Level

200

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble
ethanol: soluble

application(s)

forensics and toxicology

SMILES string

OS(O)(=O)=O.CC(N)Cc1ccccc1.CC(N)Cc2ccccc2

InChI

1S/2C9H13N.H2O4S/c2*1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2*2-6,8H,7,10H2,1H3;(H2,1,2,3,4)/t2*8-;/m00./s1

InChI key

PYHRZPFZZDCOPH-QXGOIDDHSA-N

Gene Information

human ... SLC18A2(6571)

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Application

D-Amphetamine hemisulfate salt has been used in oxidative fermentative (OF) test, and exploratory test.

Biochem/physiol Actions

D-Amphetamine is an active isomer of amphetamine. It induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites, which blocks catecholamine reuptake.

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Although scientific research using mammalian models has made great strides in uncovering the enigmatic neural and molecular mechanisms orchestrating the state of drug addiction, a complete understanding has thus far eluded researchers. The complexity of the task has led to
Timothy J O'Neal et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(8), 1251-1262 (2019-11-21)
Opioid addiction has been declared a public health emergency, with fatal overdoses following relapse reaching epidemic proportions and disease-associated costs continuing to escalate. Relapse is often triggered by re-exposure to drug-associated cues, and though the neural substrates responsible for relapse
A M Barr et al.
Pharmacology, biochemistry, and behavior, 64(3), 597-604 (1999-11-05)
The present study sought to determine the effect of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in male rats. Tests were conducted every 5 days until stable levels of sexual behavior were obtained. With repeated testing
Stephanie A Carmack et al.
Neuroscience letters, 468(1), 18-22 (2009-10-27)
Much research is focused on developing novel drugs to improve memory. In particular, psychostimulants have been shown to enhance memory and have a long history of safe use in humans. In prior work, we have shown that very low doses
Yan Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(3), 1217-1222 (2010-01-19)
The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating, a behavior in which central dopamine (DA) has been implicated. Here, we used male prairie voles to examine the effects of drug exposure
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