Skip to Content
Merck
All Photos(1)

Key Documents

246R-1

Sigma-Aldrich

E-cadherin (EP700Y) Rabbit Monoclonal Primary Antibody

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP700Y, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (246R-14)
vial of 0.5 mL concentrate (246R-15)
bottle of 1.0 mL predilute (246R-17)
vial of 1.0 mL concentrate (246R-16)
bottle of 7.0 mL predilute (246R-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG

control

breast

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

General description

E-cadherin is a transmembrane protein that is involved in cell adhesion through the formationof adherens junctions between cells. It is expressed in cells of epithelial lineage. Anti-E-cadherin stains positively in the glandular epithelium as well as carcinomas of the gastrointestinaltract and breast. E-cadherin immunohistochemistry may also aid in the differentiation ofbreast ductal carcinomas (with membranous stain) from lobular carcinomas (with loss of themembranous stain).

Quality


IVD
IVD
IVD
RUO

Linkage

E-cadherin Positive Control Slides, Product No. 246S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A J Karayiannakis et al.
Hepato-gastroenterology, 45(24), 2437-2442 (1999-02-10)
E-cadherin is a cell-cell adhesion molecule involved in tumor progression and metastasis. We evaluated the E-cadherin expression pattern in gastric cancer and investigated its relationship to histopathological features. The expression of E-cadherin was evaluated in 83 formalin-fixed, paraffin-embedded specimens of
G Acs et al.
American journal of clinical pathology, 115(1), 85-98 (2001-02-24)
We studied the pattern of E-cadherin expression in 183 invasive carcinomas (100 ductal, 42 lobular, 41 with mixed ductal and lobular features) and 198 in situ carcinomas (131 ductal, 53 lobular, 14 in situ with ductal and lobular features) by
Amer Wahed et al.
Annals of diagnostic pathology, 6(6), 349-351 (2002-12-13)
Pleomorphic lobular carcinoma is a recently described entity separated from classical lobular carcinoma by cytologic pleomorphism. It can have an aggressive clinical course with a higher frequency of recurrence. Histologic differentiation with ductal carcinoma may be difficult, but it is
A Simsir et al.
Diagnostic cytopathology, 20(3), 125-130 (1999-03-23)
The distinction between reactive mesothelial cells (RMC), malignant mesothelioma (MM), and metastatic adenocarcinoma (ACA) in pleural effusions may be impossible based on morphology alone. E-cadherin, N-cadherin, and calretinin are newly described immunocytochemical markers which can potentially be utilized for facilitating
A C Han et al.
Cancer, 87(2), 83-86 (1999-05-05)
Cadherins are a family of cell-cell adhesion proteins. The homotypic binding of cadherins is critical for cell sorting and tissue formation during organogenesis. Different cadherin subtypes show lineage specific tissue expression, which has been exploited to differentiate histologically similar tumors
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service