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Key Documents

T8625

Sigma-Aldrich

L-Threonine

≥98% (HPLC)

Synonym(s):

(2S,3R)-2-Amino-3-hydroxybutyric acid

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About This Item

Linear Formula:
CH3CH(OH)CH(NH2)CO2H
CAS Number:
Molecular Weight:
119.12
Beilstein:
1721646
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product name

L-Threonine, reagent grade, ≥98% (HPLC)

grade

reagent grade

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to off-white

mp

256 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL, clear, colorless

application(s)

cell analysis

SMILES string

C[C@@H](O)[C@H](N)C(O)=O

InChI

1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1

InChI key

AYFVYJQAPQTCCC-GBXIJSLDSA-N

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Application

L-threonine has been used for the selection of transformed cells. It has also been used to study the effects of amino acids in promoting food consumption in Drosophila melanogaster.

Biochem/physiol Actions

L-Threonine is an essential amino acid. It is involved in the synthesis of mucin, a protein supporting intestinal function and integrity. L-threonine has a role in the immune system, in O-linked glycosylation, protein phosphorylation and glycine synthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra M. Gehring
Bio-protocol, 7(22), 1-26 (2017)
An internal sensor detects dietary amino acids and promotes food consumption in Drosophila
Zhe Yang
Nature, 1-36 (2017)
Tamara Seredenina et al.
Antioxidants & redox signaling, 23(5), 490-513 (2014-02-04)
Voltage-gated proton channels are increasingly implicated in cellular proton homeostasis. Proton currents were originally identified in snail neurons less than 40 years ago, and subsequently shown to play an important auxiliary role in the functioning of reactive oxygen species (ROS)-generating
Catherine E Gleason et al.
The Journal of clinical investigation, 125(1), 117-128 (2014-11-22)
The epithelial Na+ channel (ENaC) is essential for Na+ homeostasis, and dysregulation of this channel underlies many forms of hypertension. Recent studies suggest that mTOR regulates phosphorylation and activation of serum/glucocorticoid regulated kinase 1 (SGK1), which is known to inhibit
Yongxian Zhuang et al.
PloS one, 9(9), e108444-e108444 (2014-09-26)
Different cancer cells exhibit altered sensitivity to metformin treatment. Recent studies suggest these findings may be due in part to the common cell culture practice of utilizing high glucose, and when glucose is lowered, metformin becomes increasingly cytotoxic to cancer

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