C7129

Citric acid monohydrate

reagent grade, ≥98% (GC/titration)

• Synonym(s): 2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
• Linear Formula: HOC(COOH)(CH₂COOH)₂ · H₂O
• CAS Number: 5949-29-1
• Molecular Weight: 210.14
• Beilstein: 4018641
• EC Number: 201-069-1
• MDL number: MFCD00149972
• UNSPSC Code: 12352100
• PubChem Substance ID: 24892935
• NACRES: NA.21

Properties

• grade: reagent grade
• Assay: ≥98% (GC/titration)
• form: powder
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• solubility: H₂O: 100 mg/mL, clear, colorless (Turbidity)
• functional group: carboxylic acid
• SMILES string: OC(CC(O)(C(O)=O)CC(O)=O)=O.O
• InChI: 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
• InChI key: YASYEJJMZJALEJ-UHFFFAOYSA-N

Description

General description

Citric acid monohydrate(CAM) is an organic acid. It can be produced by crystallization from mother liquor of citric acid solution at 20-25°C during citric acid synthesis. Its molar enthalpy of solution in water has been reported to be Δ_solH_m (298.15K, m = 0.0203molkg^-1) = (29061±123)Jmol^-1. An investigation of its crystal growth kinetics indicates that growth is linearly dependent on size.

Application

Citric acid monohydrate may be used:

• To prepare citric acid solution employed in the acetone method of ⁶⁸Ga pre-purification and radiolabeling technique.
• To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes.
• To improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 345.0 °F - closed cup
• Flash Point(C): 173.9 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves