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A8251

Sigma-Aldrich

Acriflavine hydrochloride

Powder

Synonym(s):

3,6-Diamino-10-methylacridinium chloride hydrochloride, Euflavine

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About This Item

CAS Number:
8063-24-9
Beilstein:
6265525
MDL number:
MFCD00069039
UNSPSC Code:
12171500
PubChem Substance ID:
24891216
NACRES:
NA.47

product name

Acriflavine hydrochloride, fluorescent dye

Quality Level

200

form

powder

composition

Acriflavine HCL content, 10-50%
Proflavine HCL, 25-70%

technique(s)

microbe id | staining: suitable

color

faint brown to brown, and Orange to Dark Orange and Red to Very Dark Red

mp

260 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Cl-].Cl[H].Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46

InChI

1S/C14H13N3.C13H11N3.3ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;;;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;3*1H

InChI key

MKLTXAHQKDVBLY-UHFFFAOYSA-N

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Application

In living mice, acriflavine hydrochloride has been used in the confocal laser endomicroscopy to check the crypt structure in mucosa. It has also been used in Neurospora strain selection by checking the acriflavine resistance.

Biochem/physiol Actions

Acriflavine hydrochloride is a fluorescent dye. It is used as a topical contrast agent. It mainly stains nuclei and is applied to tissues before microscopy.

Other Notes

A mixture of 3,6-diamino-10-methylacridinium (acriflavin) and 3,6-diaminoacridine (proflavin)

Signal Word

Danger

Hazard Statements

H302,H318,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SHBR5332
SHBR8114
SHBR3518
SHBM0542
SHBQ3710

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G Duarte et al.
International journal of food microbiology, 52(3), 163-168 (2000-03-25)
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period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock.
Emerson JM, et al.
Proceedings of the National Academy of Sciences of the USA, 112, 15707-15712 (2015)
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Frontiers in aging neuroscience, 12, 54-54 (2020-03-27)
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