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Key Documents

55513

Supelco

Spermine

analytical standard

Synonym(s):

N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine

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About This Item

Linear Formula:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
CAS Number:
Molecular Weight:
202.34
Beilstein:
1750791
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

Pricing and availability is not currently available.

grade

analytical standard

Quality Level

Assay

≥99.0% (GC)
97.0-103.0% (T)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% carbonate
≤0.5% spermidine

bp

150 °C/5 mmHg (lit.)

mp

28-30 (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

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1 of 4

This Item
S42648559085558
Spermine analytical standard

55513

Spermine

Spermine suitable for cell culture, BioReagent

S4264

Spermine

Spermine ≥99.0% (GC)

85590

Spermine

Spermidine BioUltra, for molecular biology, ≥99.5% (GC)

85558

Spermidine

grade

analytical standard

grade

-

grade

-

grade

for molecular biology

application(s)

cleaning products
cosmetics
food and beverages
personal care

application(s)

-

application(s)

-

application(s)

advanced drug delivery
genomic analysis

format

neat

format

-

format

-

format

-

assay

≥99.0% (GC)

assay

≥96%

assay

≥99.0% (GC)

assay

≥99.5% (GC)

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    R Amendola et al.
    Current cancer drug targets, 9(2), 118-130 (2009-03-12)
    The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating cells attracted the interest of scientists during last decades, addressing PA depletion as a new
    Mg-ATP binding: its modification by spermine, the relevance to cytosolic Mg2+ buffering, changes in the intracellular ionized Mg2+ concentration and the estimation of Mg2+ by 31P-NMR.
    D Lüthi et al.
    Experimental physiology, 84(2), 231-252 (1999-05-05)
    M Zhang et al.
    Critical care medicine, 28(4 Suppl), N60-N66 (2000-05-12)
    Spermine, a naturally occurring polyamine, is a ubiquitous structural component of all eukaryotic cells. Regenerating tissues produce higher levels of spermine, and injured or dying cells release spermine into the extracellular milieu, so that tissue levels increase significantly at inflammatory
    Anthony E Pegg et al.
    Cellular and molecular life sciences : CMLS, 67(1), 113-121 (2009-10-28)
    Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function. Structural and biochemical studies reveal
    An activity-dependent spermine-mediated mechanism that modulates glutamate transmission.
    Domenico E Pellegrini-Giampietro
    Trends in neurosciences, 26(1), 9-11 (2002-12-24)

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