17929
O-Methyl-O′-succinylpolyethylene glycol 5′000
Synonym(s):
Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate
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About This Item
Linear Formula:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS Number:
MDL number:
UNSPSC Code:
51171641
NACRES:
NA.26
Recommended Products
form
powder
Quality Level
mol wt
Mr ~5100
mp
56-60 °C
Ω-end
carboxylic acid
α-end
methoxy
storage temp.
−20°C
Application
Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.
Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG
Biochem/physiol Actions
O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Kanjiro Miyata (The University of Tokyo, Japan) provides insights on the rational design of polymeric materials for “smart” oligonucleotide delivery.
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