SCT059
BioTracker TiY Vimentin Live Cell Dye
Live cell imaging probe for identifying tumor initiating cells (TICs) in a variety of epithelial cancers, including lung cancer. The TiY probe binds to vimentin expressed in TICs.
Synonym(s):
Live cell imaging probe, Tumor Initiating Cell (TIC) dye
About This Item
Recommended Products
Assay
≥98% (H-NMR)
≥98% (HPLC)
≥98% (LC/MS)
≥98% (elemental analysis)
technique(s)
cell based assay: suitable
detection method
fluorometric
General description
BioTracker TiY Vimentin is a live cell fluorescent dye that selectively stains TICs over differentiated tumor cells or normal cells. TiY can be used for visualization and enrichment of functionally active TICs from patient tumors. TiY displays better selectivity for tumorigenic cells than a CD166 antibody and can be used for TiY-staining-based cell sorting for TICs in various types of cancer (lung, CNS, melanoma, breast, renal, ovarian, colon and prostate cancer). At high concentrations, TiY shows selective anti-TIC activity over non-TIC and normal tissue cells.
Spectral Properties
Absorbance: 553 nm
Emission: 573 nm
References
Lee Y et al. Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2851-2854.
Application
Cell Imaging
Live Cell Dye
Quality
Molar Mass: 541.87 g/mol
Physical form
Storage and Stability
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Other Notes
Disclaimer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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