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8.06722

Sigma-Aldrich

Nickel(II) chloride

anhydrous for synthesis

Synonym(s):

Nickel(II) chloride, Nickel dichloride

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About This Item

Empirical Formula (Hill Notation):
Cl2Ni
CAS Number:
7718-54-9
Molecular Weight:
129.60
UNSPSC Code:
12352302
EC Index Number:
231-743-0
NACRES:
NA.22

vapor pressure

1.33 hPa ( 671 °C)

Quality Level

200

form

powder

potency

105 mg/kg LD50, oral (Rat)

pH

4 (20 °C, 500 g/L in H2O)

mp

1009 °C

density

3.55 g/cm3

storage temp.

2-30°C

InChI

1S/2ClH.Ni/h2*1H;/q;;+2/p-2

InChI key

QMMRZOWCJAIUJA-UHFFFAOYSA-L

Application

Nickel(II) chloride can be used as a catalyst:
  • To synthesize acyclic and cyclic dithioacetals via thioacetalization of aldehydes.
  • To prepare α-aminonitrile derivatives via a one-pot, three-component coupling reaction of aldehydes, amines, and trimethylsilyl cyanide.
  • In the hydrodefluorination of fluoroarenes in the presence of lithium triethylborohydride.

Analysis Note

Assay (complexometric): 98.0 - 102.0 %
Loss on drying (150 °C; 3h): ≤ 1.0 %

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

Target Organs

Lungs

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Highly Efficient Nickel (II) Chloride/Bis (tricyclohexylphosphine) nickel (II) Chloride-Cocatalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride
Zhao Wenwen, et al.
Advanced Synthesis & Catalysis, 354(4), 574-578 (2012)
Nickel (II) chloride catalyzed one-pot synthesis of α-aminonitriles
De Surya Kanta
J. Mol. Catal. A: Chem., 225(2), 169-171 (2005)
Nickel (II) chloride as an efficient and useful catalyst for chemoselective thioacetalization of aldehydes
Khan AT, et al.
Tetrahedron Letters, 44(5), 919-922 (2003)
Highly Efficient Nickel (II) Chloride/Bis (tricyclohexylphosphine) nickel (II) Chloride-Cocatalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride
Zhao Wenwen, et al.
advanced synthesis and catalysis, 354(4), 574-578 (2012)

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