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880124P

Avanti

DSPE-PEG(2000) Folate

Avanti Research™ - A Croda Brand 880124P, powder

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
1236288-25-7
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (880124P-1mg)
pkg of 1 × 10 mg (880124P-10mg)
pkg of 1 × 5 mg (880124P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880124P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C

Application

DSPE-PEG(2000) Folate has been mixed in chloroform for folate-targeted PEGylated liposomes preparation.

Biochem/physiol Actions

Folate offers protection against megaloblastic anaemia during pregnancy.

Packaging

5 mL Amber Glass Screw Cap Vial (880124P-10mg)
5 mL Amber Glass Screw Cap Vial (880124P-1mg)
5 mL Amber Glass Screw Cap Vial (880124P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Microfluidic synthesis of PEG-and folate-conjugated liposomes for one-step formation of targeted stealth nanocarriers
Hood RR, et al.
Pharmaceutical Research, 30(6), 1597-1607 (2013)
Folate and human reproduction.
Tamura T and Picciano MF
American Journal of Clinical Nutrition, 83(5), 993-1016 (2006)
Shih-Jiuan Chiu et al.
Journal of controlled release : official journal of the Controlled Release Society, 112(2), 199-207 (2006-03-28)
A novel transferrin receptor (TfR)-targeted liposomal formulation was synthesized and evaluated for the delivery of a phosphorothioate antisense oligodeoxyribonucleotide (ODN) (G3139, oblimerson sodium, or Genasense) to Bcl-2 in K562 leukemia cells. Liposomes composed of DC-Chol/egg PC/PEG-DSPE (25:73.5:1.5, mol/mol/mol) were loaded
A Gabizon et al.
Bioconjugate chemistry, 10(2), 289-298 (1999-03-17)
Conjugates of three components, folic acid-poly(ethylene glycol)-distearoylphosphatidylethanolamine (FA-PEG-DSPE), derived from PEG with molecular masses of 2000 and 3350 Da were synthesized by a carbodiimide-mediated coupling of FA to H2N-PEG-DSPE. The conjugates were characterized by 1H NMR, MALDI-TOF, and HPLC analysis
Yonghua Zhang et al.
Analytical biochemistry, 332(1), 168-177 (2004-08-11)
Cell membrane-associated folate receptors are selectively overexpressed in certain human tumors. The high affinity of folic acid for folate receptors provides a unique opportunity to use folic acid as a targeting ligand to deliver chemotherapeutic agents to cancer cells. Folate-tethered
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