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850334P

Avanti

MAPCHO™-10

Avanti Research™ - A Croda Brand 850334P, powder

Synonym(s):

n-decylphosphocholine

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About This Item

Empirical Formula (Hill Notation):
C15H34NO4P
CAS Number:
70504-28-8
Molecular Weight:
323.41
MDL number:
MFCD07784458
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850334P-1g)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850334P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OCC[N+](C)(C)C)OCCCCCCCCCC

InChI

1S/C15H34NO4P/c1-5-6-7-8-9-10-11-12-14-19-21(17,18)20-15-13-16(2,3)4/h5-15H2,1-4H3

InChI key

VVVDGSCGBGBGFN-UHFFFAOYSA-N

General description

MAPCHO™-10/n-decylphosphocholine (DPC) is a short-chain lipid like, zwitterionic detergent.
N-decylphosphocholine is a structural analog of decanoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid maybe used as a detergent for membrane protein solubilization and purification.

Biochem/physiol Actions

Dodecylphosphocholine (DPC) is mainly used to isolate and purify membrane proteins and it also acts as a membrane-mimetic micellar environment for liquid-state nuclear magnetic resonance (NMR) studies of membrane proteins.

Packaging

30 mL Amber Wide Mouth Bottle with Screw Cap (850334P-1g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta (2012)
Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta, 1818(5), 1142-1147 (2012)
Sheeja V Vasudevan et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(15), 6847-6851 (2010-03-31)
Repair of damage to the central nervous system (CNS) is inhibited by the presence of myelin proteins that prevent axonal regrowth. Consequently, growth inhibitors and their common receptor have been identified as targets in the treatment of injury to the
D Z Liu et al.
Journal of pharmaceutical sciences, 88(11), 1161-1168 (1999-11-17)
The intestinal epithelium is a significant barrier for oral absorption of hydrophilic drugs because they cannot easily traverse the lipid bilayer of the cell membrane and their passage through the intercellular space (paracellular transport) is restricted by the tight junctions.
Binyong Liang et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(41), 16140-16145 (2007-10-04)
The bacterial outer membrane protein G (OmpG), a monomeric pH-gated porin, was overexpressed in Escherichia coli and refolded in beta-octyl glucoside micelles. After transfer into dodecylphosphocholine micelles, the solution structure of OmpG was determined by solution NMR spectroscopy at pH
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