M73206
4-Methylpiperidine
96%
Synonym(s):
γ-Pipecoline, 4-Pipecoline
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About This Item
Empirical Formula (Hill Notation):
C6H13N
CAS Number:
Molecular Weight:
99.17
Beilstein:
1083
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
96%
form
liquid
refractive index
n20/D 1.446 (lit.)
bp
124 °C (lit.)
density
0.838 g/mL at 25 °C (lit.)
SMILES string
CC1CCNCC1
InChI
1S/C6H13N/c1-6-2-4-7-5-3-6/h6-7H,2-5H2,1H3
InChI key
UZOFELREXGAFOI-UHFFFAOYSA-N
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Application
4-Methylpiperidine can be used to synthesize the following bioactive compounds:
It can also act as a deprotecting reagent for the removal of Fmoc group from amino acids during solid-phase peptide synthesis.
- dimethyl bis(4-methylpiperidine-dithiocarbamato-S,S′)-tin(IV)
- (E)-4-(4′-methylpiperidino-N-alkoxy) stilbenes
- 4-methylpiperidinoalkylthio and 4-methylpiperidinoalkoxy derivatives of (E)-chalcone
It can also act as a deprotecting reagent for the removal of Fmoc group from amino acids during solid-phase peptide synthesis.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
55.4 °F - closed cup
Flash Point(C)
13 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Synthesis and antimicrobial activity of new (E)-4-[piperidino (4'-methylpiperidino-, morpholino-) N-alkoxy] stilbenes.
Wyrzykiewicz E, et al.
European Journal of Medicinal Chemistry, 41(4), 519-525 (2006)
Preparation, Spectroscopy, Antimicrobial Assay, and X-Ray Structure of Dimethyl bis-(4-methylpiperidine dithiocarbamato-S, S)-tin (IV).
REHMAN Z, et al.
Turkish Journal of Chemistry, 31(4), 435-442 (2007)
Synthesis, physicochemical properties and antimicrobial evaluation of new (E)-chalcones.
Nowakowska Z, et al.
European Journal of Medicinal Chemistry, 43(4), 707-713 (2008)
Efficient synthesis of peptides with 4-methylpiperidine as Fmoc removal reagent by solid phase synthesis.
Galeano V, et al.
Journal of the Mexican Chemical Society, 58(4), 386-392 (2014)
Aline de Souza et al.
Drug delivery and translational research, 10(6), 1771-1787 (2020-08-26)
Peptide-mediated targeting to colorectal cancer can increase selectivity and specificity of this cancer diagnosis acting as biomarkers. The present work aimed to select peptides using the phage display technique and associate the peptides with polymeric nanospheres in order to evaluate
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