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790877

Sigma-Aldrich

Tris(2,2,2-trifluoroethyl) borate

97%

Synonym(s):

Tris(2,2,2-trifluoroethyl)borate, Sheppard Amidation Reagent, Tris(2,2,2-trifluoroethoxy)boron, Sheppard Reagent

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About This Item

Empirical Formula (Hill Notation):
C6H6BF9O3
CAS Number:
659-18-7
Molecular Weight:
307.91
MDL number:
MFCD00093768
UNSPSC Code:
12352103
PubChem Substance ID:
329768246
NACRES:
NA.22

Quality Level

100

Assay

97%

form

liquid

refractive index

n/D 1.298 (lit.)

density

1.430 g/mL at 25 °C

functional group

fluoro

SMILES string

FC(F)(F)COB(OCC(F)(F)F)OCC(F)(F)F

InChI

1S/C6H6BF9O3/c8-4(9,10)1-17-7(18-2-5(11,12)13)19-3-6(14,15)16/h1-3H2

InChI key

DIEXQJFSUBBIRP-UHFFFAOYSA-N

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Application

Reagent can promote the direct formation of amides from carboxylic acids and amines under thermal and microwave conditions.

Pictograms

Flame
GHS02

Signal Word

Warning

Hazard Statements

H226

Hazard Classifications

Flam. Liq. 3

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

109.9 °F

Flash Point(C)

43.3 °C

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ8389
MKCS2757
MKCP4222
MKCN0097
MKCL7393

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Pavel Starkov et al.
Organic & biomolecular chemistry, 9(5), 1320-1323 (2011-01-08)
Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl)
Rachel M Lanigan et al.
The Journal of organic chemistry, 78(9), 4512-4523 (2013-04-17)
B(OCH2CF3)3, prepared from readily available B2O3 and 2,2,2-trifluoroethanol, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of amines. In most cases, the amide products can be purified by a

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