708496

Acetyl chloride solution

1 M in methylene chloride

• Empirical Formula (Hill Notation): C₂H₃ClO
• CAS Number: 75-36-5
• Molecular Weight: 78.50
• MDL number: MFCD00000719
• UNSPSC Code: 12352101
• PubChem Substance ID: 329762802
• NACRES: NA.22

Properties

• form: liquid
• Quality Level: 100
• concentration: 1 M in methylene chloride
• refractive index: n20/D 1.423
• density: 1.294 g/mL at 25 °C
• functional group: acyl chloride
• SMILES string: CC(Cl)=O
• InChI: 1S/C2H3ClO/c1-2(3)4/h1H3
• InChI key: WETWJCDKMRHUPV-UHFFFAOYSA-N

Description

Application

Acetyl chloride (AcCl) can be used as:

• An acylating reagent to prepare useful key intermediates in organic synthesis.
• A reagent to convert oxathioacetals and dithioacetals into corresponding carbonyl compounds in the presence of sodium nitrite.
• An activating or acylating reagent in solid-phase organic synthesis.
• A reagent to prepare various alkyl and aryl tetrahydropyranyl ethers from corresponding alcohols.

Safety Information

• Pictograms: GHS02,GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H314,H336,H351
• Precautionary Statements: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Target Organs: Central nervous system
• WGK: WGK 2
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves