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50280

Sigma-Aldrich

Gly-His hydrochloride hydrate

≥99.0% (calc. based on dry substance, AT)

Synonym(s):

Glycyl-L-histidine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C8H12N4O3 · HCl · xH2O
CAS Number:
3486-76-8
Molecular Weight:
248.67 (anhydrous basis)
Beilstein:
3743779
MDL number:
MFCD00167964
UNSPSC Code:
12352209
PubChem Substance ID:
57651248
NACRES:
NA.22

Quality Level

100

Assay

≥99.0% (calc. based on dry substance, AT)

optical activity

[α]20/D +31.5±1.0°, c = 2% in H2O (dry matter)

reaction suitability

reaction type: solution phase peptide synthesis

impurities

~1 mol water

application(s)

peptide synthesis

SMILES string

O.Cl.NCC(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C8H12N4O3.ClH.H2O/c9-2-7(13)12-6(8(14)15)1-5-3-10-4-11-5;;/h3-4,6H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15);1H;1H2/t6-;;/m0../s1

InChI key

VGVLXWZHJBRECR-ILKKLZGPSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL4572
BCCH6228
BCBV6603
BCBP8541V
BCBJ4467V

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A Strauss et al.
FEMS microbiology letters, 127(3), 249-254 (1995-04-01)
A glycine-histidine tag (Gly3His6) was added to the C-terminus of a fusion protein consisting of the cholera toxin B-subunit (CtxB) and the IgA protease beta-domain (Iga beta). The aim was to facilitate single-step purification and to create a suitable tool
N Manoj et al.
The journal of peptide research : official journal of the American Peptide Society, 56(4), 210-217 (2000-11-18)
The crystal structures of the complexes of oxalic acid with glycyl-L-histidine and L-histidyl-L-alanine were determined. The three crystallographically independent peptide molecules in the complexes have closed conformations. The terminal carboxyl group of the dipeptide and the oxalate ion in the
Urszula Rychlewska et al.
Dalton transactions (Cambridge, England : 2003), 39(38), 8906-8913 (2010-08-21)
Monocationic gold(III) complexes with histidine-containing peptides, glycyl-L-histidine (Gly-L-His) and L-alanyl-L-histidine (L-Ala-L-His) have been synthesized and characterized by (1)H NMR spectroscopy and X-ray crystallography. The crystallized Au(III) complexes, [Au(Gly-L-His-N,N',N'')Cl]NO(3)·1.25H(2)O and [Au(L-Ala-L-His-N,N',N'')Cl]NO(3)·2.5H(2)O, were obtained from water solution at pH < 1.0. The
Michael S Kostelansky et al.
Biochemistry, 43(9), 2475-2483 (2004-03-03)
Structural analysis of recombinant fibrinogen fragment D revealed that the calcium-binding site (beta2-site) composed of residues BbetaAsp261, BbetaAsp398, BbetaGly263, and gammaGlu132 is modulated by the "B:b" interaction. To determine the beta2-site's role in polymerization, we engineered variant fibrinogen gammaE132A in
Giampiero De Sanctis et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 11(2), 153-167 (2005-12-13)
The pH dependence of redox properties, spectroscopic features and CO binding kinetics for the chelated protohemin-6(7)-L-histidine methyl ester (heme-H) and the chelated protohemin-6(7)-glycyl-L-histidine methyl ester (heme-GH) systems has been investigated between pH 2.0 and 12.0. The two heme systems appear
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