44570
Dowtherm® A
eutectic mixture of 26.5% diphenyl + 73.5% diphenyl oxide
Synonym(s):
Diphyl
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About This Item
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refractive index
n20/D 1.590
mp
12-14 °C (lit.)
functional group
phenoxy
phenyl
SMILES string
c1ccc(cc1)-c2ccccc2.O(c3ccccc3)c4ccccc4
InChI
1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;1-10H
InChI key
MHCVCKDNQYMGEX-UHFFFAOYSA-N
General description
Dowtherm® A is a thermally stable organic heat transfer fluid composed of a eutectic mixture of highly stable compounds, biphenyl, and diphenyl oxide. Dowtherm® A is suitable for high-temperature heat transfer applications up to 400 °C. This fluid can be used in both liquid and vapor phase systems.
Application
Dowtherm® A can be used as a high boiling solvent in cyclization reactions. For example, it is used to synthesize:
- 1-Hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines from 2-chloro-3-formyl quinolines.
- Isoindolinone derivatives via intramolecular Diels–Alder cycloaddition reactions of substituted pyridazines.
- Phosphorylated azaheterocycles from 2-diethoxyphosphoryl-3-methoxyacrylate via intramolecular cyclizations under thermal conditions.
Legal Information
DOWTHERM is a registered trademark of The Dow Chemical Company or an affiliated company of Dow
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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F O Dorgelo et al.
International archives of occupational and environmental health, 56(2), 129-134 (1985-01-01)
A study was carried out in a nylon producing plant to determine exposure to Dowtherm A from frequently occurring leaks in the heating system. The daily exposure to both diphenyl and diphenylether of 20 workers was determined over seven consecutive
Thermal neutron cross sections and diffusion parameters of diphenyl and Dowtherm-A using a synthetic scattering function.
Florido PC, et al.
Journal of Nuclear Materials, 185(1), 114-122 (1999)
Efficient synthesis of phosphorylated ortho-fused azaheterocycles
Modranka J and Janecki T
Tetrahedron, 67(49), 9595-9601 (2011)
[2 cases of acute dinil poisoning].
A N Kapustina et al.
Gigiena truda i professional'nye zabolevaniia, (3)(3), 50-51 (1983-03-01)
V M Sheĭbak et al.
Gigiena i sanitariia, (4)(4), 81-82 (2008-12-23)
Experiments on rats were carried out to study the effect of dinil on the animals on chronic intake of the agent in the quantities exceeding the maximum permissible concentrations by many times. Despite few biochemical changes, there was a certain
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