344648

Triethylamine trihydrofluoride

97%

• Synonym(s): Hydrogen fluoride triethylamine, TREAT-HF
• Linear Formula: (C₂H₅)₃N · 3HF
• CAS Number: 73602-61-6
• Molecular Weight: 161.21
• Beilstein: 5522945
• EC Number: 277-550-5
• MDL number: MFCD00043294
• UNSPSC Code: 12352101
• PubChem Substance ID: 24861270
• NACRES: NA.22

Properties

• Quality Level: 300
• Assay: 97%
• refractive index: n20/D 1.3915 (lit.)
• bp: 70 °C/15 mmHg (lit.)
• density: 0.989 g/mL at 25 °C (lit.)
• functional group: amine
• SMILES string: F[H].F[H].F[H].CCN(CC)CC
• InChI: 1S/C6H15N.3FH/c1-4-7(5-2)6-3;;;/h4-6H2,1-3H3;3*1H
• InChI key: IKGLACJFEHSFNN-UHFFFAOYSA-N

Description

General description

Triethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds.

Application

Mild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta.

TREAT-HF can be used in the synthesis of:

• Vicinal difluorides from epoxides.
• 3-fluoroazetidines.
• 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA).
• Multivicinal hexafluoroalkanes.
• Aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330,H314
• Precautionary Statements: P260 - P271 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): 190.4 °F - closed cup
• Flash Point(C): 88 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves