30681
L-4-Hydroxyproline methyl ester hydrochloride
≥98.0% (GC)
Synonym(s):
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride, trans-4-Hydroxyproline methyl ester hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C6H11NO3 · HCl
CAS Number:
Molecular Weight:
181.62
Beilstein:
4716932
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
≥98.0% (GC)
form
solid
reaction suitability
reaction type: solution phase peptide synthesis
application(s)
peptide synthesis
SMILES string
Cl.COC(=O)[C@@H]1C[C@@H](O)CN1
InChI
1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/m1./s1
InChI key
KLGSHNXEUZOKHH-JBUOLDKXSA-N
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Emily M Christensen et al.
The Journal of biological chemistry, 295(52), 18316-18327 (2020-10-29)
Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of
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