233781
Triisopropylsilane
98%
Synonym(s):
TIS, Triisopropylhydrosilane, Tris(1-methylethyl)silane
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About This Item
Linear Formula:
[(CH3)2CH]3SiH
CAS Number:
Molecular Weight:
158.36
Beilstein:
1733718
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
EC Index Number:
464-880-1
NACRES:
NA.22
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Quality Level
Assay
98%
form
liquid
reaction suitability
reagent type: reductant
refractive index
n20/D 1.434 (lit.)
bp
84-86 °C/35 mmHg (lit.)
density
0.773 g/mL at 25 °C (lit.)
SMILES string
CC(C)[SiH](C(C)C)C(C)C
InChI
1S/C9H22Si/c1-7(2)10(8(3)4)9(5)6/h7-10H,1-6H3
InChI key
YDJXDYKQMRNUSA-UHFFFAOYSA-N
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General description
Triisopropylsilane (TIPS) is an organosilicon compound used as a reducing agent in organic synthesis due to its relatively low toxicity, ease of handling, and its ability to selectively reduce various functional groups. It is used in the presence of a Lewis acid such as titanium (IV) chloride to selectively reduce ketones and aldehydes to their corresponding alkanes and selective reduction of epoxides to the corresponding alcohols.
Application
Triisopropylsilane can be used as a reducing agent:
- To synthesize 4-pyrrole phenylacyl peptide during solid-phase peptide synthesis.
- In transition metal complex-catalyzed reaction of amides with hydrosilanes.
- For the selective reduction of C-arylglucosides into β-C-aryl glucosides.
- To facilitate the cleavage of acetamidomethyl (Acm), 4-methoxybenzyl (Mob), and tert-butyl (But) protecting groups from cysteine (Cys) residues in the presence of trifluoroacetic acid.
- For the reduction of amides to corresponding amines in the presence of transition-metal catalysts.
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Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
100.4 °F - closed cup
Flash Point(C)
38 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tetrahedron Asymmetry, 14, 3243-3247 (2003)
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